top of page

Hines, R.M., Aquino, E. A., Khumnark, M. I., Dávila M. P., & Hines, D.J. (2022). Comparative Assessment of TSPO Modulators on Electroencephalogram Activity and Exploratory Behavior. Frontiers in Pharmacology

Hines, D.J., Contreras, A., Garcia, B., Barker, J.S., Boren, A.J., Moufawad El Achkar C, Moss, S.J., & Hines, R.M. (2022). Human ARHGEF9 intellectual disability syndrome is phenocopied by a mutation that disrupts collybistin binding to the GABAA receptor α2 subunit. Molecular Psychiatry

Contreras, A., Khumnark, M., Hines, R.M., & Hines D.J. (2021). Behavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT2A receptor activation. Scientific Reports 11:1925.


Hines R.M., Khumnark M., Macphail B., & Hines D.J. (2019). Administration of Micronized Caffeine Using a Novel Oral Delivery Film Results in Rapid Absorption and Electroencephalogram Suppression. Frontiers in Pharmacology. 10:983.

Contreras, A., Hines, D.J., & Hines, R.M. (2019). Molecular Specialization of GABAergic Synapses on the Soma and Axon in Cortical and Hippocampal Circuit Function and Dysfunction. Frontiers in Molecular Neuroscience. 12:154.

Nathanson, A.J., Zhang, Y., Smalley, J.L., Ollerhead, T.A., Rodriguez Santos, M.A., Andrews, P.M., Bope, C., Brandon, N.J., Hines, R.M., Davies, P.A., & Moss, S.J. Identification of a core amino acid motif within the α subunit of GABAARs that promotes inhibitory synaptogenesis and resilience to seizures. Accepted: Cell Reports.

Hines, R.M., Maric, H.M., Hines, D.J., Modgil, A., Panzenelli, P., Nakamura, Y., Nathanson, A.J., Cross, A., Deeb, T., Brandon, N., Davies, P., Fritschy, J.M., Schindelin, H., & Moss, S.J. (2018). Developmental seizures and mortality result from reducing GABAA Receptor α2 subunit interaction with collybistin. Nature Communications. 9(1):3130.​

Ali Rodriguez, R., Joya, C., Hines, R.M. (2018). Common Ribs of Inhibitory Synaptic Dysfunction in the Umbrella of Neurodevelopmental Disorders. Frontiers in Molecular Neuroscience. 11:132.

McNeela, A.M., Bernick, C., Hines, R.M., & Hines, D.J. (2018). TSPO regulation in reactive gliotic diseases. Journal of Neuroscience Research. 96(6):978-988.

Mircsof, D., Langouët, M., Rio, M., Moutton, S., Siquier-Pernet, K., Bole-Feysot, C., Cagnard, N., Nitschke, P., Gaspar, L., Žnidarič, M., Alibeu, O., Fritz, A.K., Wolfer, D.P., Schröter, A., Bosshard, G., Rudin, M., Koester, C., Crestani, F., Seebeck, P., Boddaert, N., Prescott, K.; DDD Study, Hines, R.M, Moss, S.J., Fritschy, J.M., Munnich, A., Amiel, J., Brown, S.A., Tyagarajan, S.K., & Colleaux, L. (2015). Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects. Nature Neuroscience. 18(12):1731-6.

Silayeva, L., Deeb, T.Z., Hines, R.M., Kelley, M.R., Munoz, M.B., Lee, H.H., Brandon, N.J., Dunlop, J.,

Maguire, J., Davies, P.A., Moss, S.J. (2015). KCC2 activity is critical in limiting the onset and severity of status epilepticus. Proceedings of the National Academy of Sciences.  112(11):3523-8.

 Engin, E., Bakhurin, K.I., Smith, K.S., Hines, R.M., Reynolds, L.M., Tang, W., Sprengel, R., Moss, S.J., & Rudolph, U. (2014). Neural basis of benzodiazepine reward: Requirement for α2 containing GABAA receptors in the nucleus accumbens. Neuropsychopharmacology. 39(8):1805-15.

Hines, R.M., Hines, D.J., Houston, C.M., Mukherjee, J., Haydon, P.G., Tretter, V., Smart, T. & Moss, S.J. (2013). Impaired GABAA receptor clustering directly contributes to cognitive deficits in a schizophrenia model. Proceedings of the National Academy of Sciences. 110(41):16628-33.

Vithlani, M.*, Hines, R.M. *, Zhong, P. *, Terunuma, M., Hines, D.J., Revilla-Sanchez, R., Jurd, R., Haydon, P.G., Rios, M., Brandon, N., Yan, Z., Moss, S.J. (2013). The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABAAR γ2 subunit. Journal of Neuroscience. 33(39):15567-77.

Kretschmannova, K.*, Hines, R.M.*, Revilla-Sanchez, R., Tretter, V., Jurd, R., Kelz, M.B., Moss, S.J., Davies, P.A. (2013). Enhanced tonic inhibition contributes to the hypnotic and amnesic actions of intravenous anesthetics. Journal of Neuroscience. 33(17):7264-73.

Hines, D.J., Choi, H.B., Hines, R.M., Phillips, A.G. & MacVicar, B.A. (2013). Prevention of LPS-induced microglia activation, cytokine production and sickness behavior with TLR4 receptor interfering peptides. PLOS One. 8(3):e60388. doi: 10.1371.

Hines, D.J., Schmitt, L.I., Hines, R.M., Moss, S.J., Haydon, P.G. (2013). Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Translational Psychiatry. Jan 15; 3:e212. doi: 10.1038/tp.2012.136.

Hines, R.M., Davies, P.A., Moss, S.J., Maguire, J. (2011). Functional regulation of GABAA receptors in nervous system pathologies. Current Opinion in Neurobiology. 22(3):552-8.

Singaraja, R.R., Huang, K., Sanders, S.S., Milnerwood, A.J., Hines, R.M, Lerch, J.P., Franciosi, S., Drisdel,  R.C., Vaid, K., Young, F.B., Doty, C., Wan, J., Bissada, N., Henkelman, R.M., Green, W.N., Davis, N.G., Raymond, L.A., Hayden, M.R. (2011). Altered palmitoylation and neuropathological deficits in mice lacking HIP14. Human Molecular Genetics, 20(20):3899-909.

Milnerwood, A.J., Gladding, C.M., Pouladi, M.A., Kaufman, A.M., Hines, R.M., Boyd, J.D., Ko, R.W.Y., Vasuta, O.C., Graham, R.K., Hayden, M.R., Murphy, T.H., Raymond, L.A. (2010). Early increase in extrasynaptic NMDA receptor signalling and expression contributes to phenotype onset in Huntington's disease mice. Neuron, 65(2):178-90.

Hines, R.M., Kang, R., Goytain, A., Quamme, G.A. (2010). The golgi-specific DHHC zinc finger protein,  GODZ, mediates membrane Ca2+ transport. Journal of Biological Chemistry, 285(7):4621-8.

Dahlhaus, R. *, Hines, R.M. *, Eadie, B. *, Kannangara, T., Hines, D.J., Brown, C.E., Christie, B. & El- Husseini, A. (2009). Learning deficits, impaired LTP and altered synaptic excitation-inhibition ratio in mice over-expressing Neuroligin 1. Hippocampus, 20(2):305-22.

Hines, D.J., Hines, R.M., Mulligan, S., & MacVicar, B.A. (2009). Microglia processes block the spread of damage in the brain and require functional chloride channels. Glia, 15;57(15):1610-8.

Krivosheya, D., Tapia, L., Levinson, J.N. Hines, R.M., Huang, K., Ting, A.K., Kang, Y., Craig, A.M., Mei, L., Bamji, S.X., & El-Husseini, A. (2008). ERBB4-Neuregulin signalling modulates synapse development and dendritic arborisation through distinct mechanisms. Journal of Biological Chemistry, 283(47):32944-56.

Goytain, A., Hines, R.M., & Quamme, G.A. (2008). Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions: Palmitoyl acytransferase and Mg2+ transport. Journal of Biological Chemistry, 283(48):33365-74.

Goytain, A., Hines, R.M., & Quamme, G.A. (2008). Functional Characterization of NIPA2, a Selective Mg2+ Transporter. The American Journal of Physiology - Cell Physiology, 295(4):C944-53.

Hines, R.M., Wu, L., Hines, D.J., Steenland, H., Mansour, S., Dahlhaus, R., Singaraja, R.R., Cao, X., Sammler, E., Hormuzdi, S.G., Zhuo, M., & Alaa El-Husseini. (2008). Synaptic imbalance, stereotypies and impaired social interactions in mice with altered neuroligin 2 expression. Journal of Neuroscience, 28(24):6055-67.

Goytain, A., Hines, R.M., El-Husseini, A., & Quamme, G.A. (2007). NIPA1, the basis for autosomal dominant hereditary spastic paraplegia syndrome, encodes a functional Mg2+ transporter. Journal of Biological Chemistry, 282(11):8060-8.

Lise, M.F., Wong, T.P., Trinh, A., Hines, R.M., Liu, L., Kang, R., Hines, D.J., Lu, J., Goldenring, J.R., Wang,  Y.T., & El-Husseini, A. (2006). Involvement of myosin Vb in glutamate receptor trafficking. Journal of Biological Chemistry, 281(6):3669-78.

Kleim, J.A., Hogg, T.M., VandenBerg, P.M., Cooper, N.R., Bruneau, R., & Remple, M. (2004). Cortical synaptogenesis and motor map reorganization occur during late, but not early, phase of motor skill learning. Journal of Neuroscience, 24, 628-33.

Kleim, J.A., Bruneau, R., Calder, K., Pocock, D., VandenBerg, P. & Nader, K. (2003). Functional organization of adult motor cortex is dependent upon continued protein synthesis. Neuron, 40, 167-176.

Kleim, J.A., Bruneau, R., VandenBerg P., MacDonald, E., Mulrooney, R. & Pocock, D. (2003). Motor cortex stimulation enhances motor recovery and reduces peri-infarct dysfunction following ischemic insult. Neurological Research, 25, 789-93.

Kleim, J.A., Freeman, J.H., Bruneau, R., Nolan, B.C., Cooper, N.R., Zook, A. & Walters, D. (2002). Synapse formation underlies memory formation in the mammalian cerebellum. Proceedings of the National Academy of Sciences, 99:13228-13231.

Remple, M.S., Bruneau, R.M., VandenBerg, P.M., Goertzen, C. & Kleim, J.A. (2001). Sensitivity of cortical movement representations to motor experience: Evidence that skill learning but not strength training induces functional organization. Behavioral Brain Research, 123, 133-141.

bottom of page