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Arias HR, Rudin D, Hines DJ, Contreras A, Gulsevin A, Manetti D, Anouar Y, De Deurwaerdere P, Meiler J, Romanelli MN, Liechti ME, Chagraoui A. (2024). The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation. European journal of pharmacology, 20:176329. 

Hines, R.M., Aquino, E. A., Khumnark, M. I., Dávila M. P., & Hines, D.J. (2022). Comparative Assessment of TSPO Modulators on Electroencephalogram Activity and Exploratory Behavior. Frontiers in Pharmacology


Hines, D.J., Contreras, A., Garcia, B., Barker, J.S., Boren, A.J., Moufawad El Achkar C, Moss, S.J., & Hines, R.M. (2022). Human ARHGEF9 intellectual disability syndrome is phenocopied by a mutation that disrupts collybistin binding to the GABAA receptor α2 subunit. Molecular Psychiatry

Contreras, A., Khumnark, M., Hines, R.M., & Hines, D.J. (2021). Behavioral arrest and a characteristic slow waveform are hallmark responses to selective 5-HT2A receptor activation. Scientific Reports 11:1925.


Hines R.M., Khumnark M., Macphail B., & Hines D.J. (2019). Administration of Micronized Caffeine Using a Novel Oral Delivery Film Results in Rapid Absorption and Electroencephalogram Suppression. Frontiers in Pharmacology. 10:983.

Contreras, A., Hines, D.J., & Hines, R.M. (2019). Molecular Specialization of GABAergic Synapses on the Soma and Axon in Cortical and Hippocampal Circuit Function and Dysfunction. Frontiers in Molecular Neuroscience. 12:154.

Hines, R.M., Maric, H.M., Hines, D.J., Modgil, A., Panzenelli, P., Nakamura, Y., Nathanson, A.J., Cross, A., Deeb, T., Brandon, N., Davies, P., Fritschy, J.M., Schindelin, H., & Moss, S.J. (2018). Developmental seizures and mortality result from reducing GABAA Receptor α2 subunit interaction with collybistin. Nature Communications. 9(1):3130.​

McNeela, A.M., Bernick, C., Hines, R.M., & Hines, D.J. (2018). TSPO regulation in reactive gliotic diseases. Journal of Neuroscience Research. 96(6):978-988.

Hines, D.J., & Haydon, P.G. (2014). Astrocyte signaling: from synapses to psychiatric disorders. Philosophical Transactions of the Royal Society of London B - Biological Sciences. 369.

Classadonte, J., Dong, J.H., Hines, D.J., &; Haydon, P.G. (2013). Astrocytic regulation of synaptic NMDA receptors modulates seizure activity. Proceedings of the National Academy of Sciences. 110(43):17540-5.

Vithlani, M., Hines, R.M., Zhong, P., Terunuma, M., Hines, D.J., Revilla-Sanchez, R., Jurd, R., Haydon, P.G., Rios, M., Brandon, N., Yan, Z., Moss, S.J. (2013). The ability of BDNF to modify neurogenesis and depressive-like behaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA A R γ2 subunit. Journal of Neuroscience. 33(39):15567-77.

Hines, R.M., Hines, D.J., Houston, C.M., Mukherjee, J., Haydon, P.G., Tretter, V., Smart, T., & Moss, S.J. (2013). Impaired GABA A receptor alpha2 subunit clustering directly contributes to cognitive deficits and gamma oscillaitons. Proceedings of the National Academy of Sciences. 110(41):16628-33.

Hines, D.J., Choi, H.B., Hines, R.M., Phillips, A.G., & MacVicar, B.A. (2013). Prevention of LPS-induced microglia activation, cytokine production and sickness behavior with TLR4 receptor interfering peptides. Public Library of Science (PLoS) One. 8(3):e60388. doi: 10.1371.

Hines, D.J., & Haydon, P.G. (2013). Inhibition of the SNARE sensitive pathway in astrocytes attenuates damage following stroke. Journal of Neuroscience. 33(17):7264-73.

Hines, D.J., Schmitt, L.I., Hines, R.M., Moss, S.J., &Haydon, P.G. (2013). Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Translational Psychiatry. 3:e212.doi: 10.1038/tp.2012.136.

Tai, C., Hines, D.J., Choi, H.B., MacVicar, B.A. (2011). Plasma membrane insertion of TRPC5 channels contributes to the cholinergic plateau potential in hippocampal CA1 pyramidal neurons. Hippocampus21(9):958–967.

Dahlhaus, R., Hines, R.M., Eadie, B.D., Kannangara, T.S., Hines, D.J., Brown, C.E., Christie, B.R., El-Husseini, A. (2009). Overexpression of the cell adhesion protein neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ratio of excitation to inhibition in the hippocampus. Hippocampus20(2):305-22.

Hines, D.J., Hines, R.M., Mulligan, S.J., MacVicar, B.A. (2009). Microglia processes block the spread of damage in the brain and require functional chloride channels. Glia. 57(15):1610-8.

Thompson, R.J., Jackson, M.F., Olah, M.E., Rungta, R.L., Hines, D.J., Beazely, M.A., MacDonald, J.F., MacVicar, B.A. (2008). Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science. 322(5907):1555-9.

Hines, R.M., Wu, L., Hines, D.J., Steenland, H., Mansour, S., Dahlhaus, R., Singaraja, R.R., Cao, X., Sammler, E., Hormuzdi, S.G., Zhuo, M., El-Husseini, A. (2008). Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. Journal of Neuroscience.28(24):6055-67.

Lisé, M.F., Wong, T.P., Trinh, A., Hines, R.M., Liu, L., Kang, R., Hines, D.J., Lu, J., Goldenring, J.R., Wang, Y.T., El-Husseini, A. (2006). Involvement of myosin Vb in glutamate receptor trafficking. Journal of Biological Chemistry. 281(6):3669-78.

Hines, D.J., Whishaw, I.Q. (2005). Home bases formed to visual cues but not to self-movement (dead reckoning) cues in exploring hippocampectomized rats. European Journal of Neuroscience. 22(9):2363-75.

Clark, B.J., Hines, D.J., Hamilton, D.A., Whishaw, I.Q. (2005). Movements of exploration intact in rats with hippocampal lesions. Behavioral Brain Research. 163(1):91-9.

Wallace, D.G., Hines, D.J., Pellis, S.M., Whishaw, I.Q. (2002). Vestibular information is required for dead reckoning in the rat. Journal of Neuroscience. 22(22):10009-17.

Wallace, D.G., Hines, D.J., Whishaw, I.Q. (2002). Quantification of a single exploratory trip reveals hippocampal formation mediated dead reckoning. Journal of Neuroscience Methods. 113(2):131-45.

Whishaw, I.Q., Hines, D.J., Wallace, D.G. (2001). Dead reckoning (path integration) requires the hippocampal formation: evidence from spontaneous exploration and spatial learning tasks in light (allothetic) and dark (idiothetic) tests. Behavioral Brain Research. 127(1-2):49- 69.

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